Find hotels in Santee, SC from $61

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Compare 273 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Baymont by Wyndham Santee

2.5 star property
8.0 out of 10, Very Good, (1293)
"Great price and rooms met my expectations "
The price is $89
includes taxes & fees
$80 per night
May 4 - May 5
Baymont by Wyndham Santee

Hampton Inn Santee-I-95

2.5 star property
9.6 out of 10, Exceptional, (998)
"Friendly staff, nice breakfast. "
The price is $152
includes taxes & fees
$137 per night
May 25 - May 26
Hampton Inn Santee-I-95

Fairfield Inn & Suites by Marriott Santee

2.5 star property
9.8 out of 10, Exceptional, (1005)
"Very nice place for an overnight stay. "
The price is $159
includes taxes & fees
$143 per night
May 11 - May 12
Fairfield Inn & Suites by Marriott Santee

Tru By Hilton Santee

2.5 star property
9.0 out of 10, Wonderful, (401)
"Very nice stay when on the way to Florida "
The price is $122
includes taxes & fees
$110 per night
May 18 - May 19
Tru By Hilton Santee

Comfort Inn & Suites Santee

2.5 star property
8.0 out of 10, Very Good, (981)
"Nice place and clean, good service."
The price is $122
includes taxes & fees
$110 per night
May 11 - May 12
Comfort Inn & Suites Santee

Best Western Plus Santee Inn

2.5 star property
8.8 out of 10, Excellent, (1001)
"The property was very clean breakfast was a plus and staff was very helpful"
The price is $127
includes taxes & fees
$115 per night
May 11 - May 12
Best Western Plus Santee Inn

Holiday Inn Santee by IHG

3.0 star property
8.2 out of 10, Very Good, (877)
"Second time staying there , very nice place "
The price is $145
includes taxes & fees
$131 per night
Jun 1 - Jun 2
Holiday Inn Santee by IHG

Quality Inn & Suites

2.5 star property
6.0 out of 10, (362)
"I've stayed at this location many times. It's my first overnight on my way up and down the coast from Maryland to Florida. The rooms are comfortable, clean and quiet."
The price is $70
includes taxes & fees
$64 per night
May 8 - May 9
Quality Inn & Suites

Travelodge by Wyndham Santee

2.0 star property
7.0 out of 10, Good, (614)
"Check in was quick and breakfast was good "
The price is $68
includes taxes & fees
$61 per night
May 26 - May 27
Travelodge by Wyndham Santee

Econo Lodge

2.0 star property
6.4 out of 10, (307)
"Check in was easy."
The price is $75
includes taxes & fees
$68 per night
May 15 - May 16
Econo Lodge

Red Roof Inn Santee

2.0 star property
6.6 out of 10, (603)
"Great place for the price to stop for the night. "
The price is $74
includes taxes & fees
$67 per night
Jun 1 - Jun 2
Red Roof Inn Santee

Super 8 by Wyndham Santee

2.0 star property
6.8 out of 10, (425)
"Great place. Easy to walk to places to eat "
The price is $83
includes taxes & fees
$75 per night
May 4 - May 5
Super 8 by Wyndham Santee

Ramada by Wyndham Santee I-95

2.0 star property
6.2 out of 10, (521)
"The property needs some work but it was quiet and close to a few restaurants we could walk to."
The price is $93
includes taxes & fees
$84 per night
May 6 - May 7
Ramada by Wyndham Santee I-95

Bells Marina & Resort

2.5 star property
8.6 out of 10, Excellent, (60)
"Our room was very clean. The owner introduced himself and was very helpful. The lake was beautiful. Only complaint....we were on the bottom floor and the person above us....we could hear his every footstep...."
The price is $98
includes taxes & fees
$88 per night
May 18 - May 19
Bells Marina & Resort

Peach Tree Inn

2.5 star property
7.2 out of 10, Good, (115)
"Very sweet and professional young lady at checkin. Asked if we need anything she will personally take care of it. Room was very clean."
The price is $81
includes taxes & fees
$75 per night
May 4 - May 5
Peach Tree Inn

Starlight Stays

2.5 star property
6.6 out of 10, (4)
"It was nice for the area "
The price is $81
includes taxes & fees
$72 per night
May 8 - May 9
Starlight Stays

Fairfield Inn by Marriott Orangeburg

2.5 star property
8.4 out of 10, Very Good, (587)
"Loved breakfast & quiet stay"
The price is $112
includes taxes & fees
$101 per night
May 26 - May 27
Fairfield Inn by Marriott Orangeburg

Comfort Inn & Suites

2.5 star property
8.0 out of 10, Very Good, (473)
"Spacious room was very clean and quiet"
The price is $147
includes taxes & fees
$132 per night
May 11 - May 12
Comfort Inn & Suites

Baymont by Wyndham Manning

2.5 star property
6.8 out of 10, (1001)
"We wish there were more dining options available locally. "
The price is $97
includes taxes & fees
$87 per night
May 15 - May 16
Baymont by Wyndham Manning

Quality Inn Manning I-95

2.5 star property
6.8 out of 10, (502)
"Very clean and nice, staff very professional "
The price is $103
includes taxes & fees
$92 per night
Jun 2 - Jun 3
Quality Inn Manning I-95
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

What are the best hotels in Santee that travelers recommend?
Holiday Inn Santee by IHG stands out as a top choice for travelers, earning a review score of 8.2. This hotel combines comfort with convenience, making it a great option for groups and solo travelers. With spacious rooms and attentive service, guests feel right at home. The hotel features a ballroom for events and room service, ensuring that all your needs are met without hassle.
What are the best family hotels in Santee?
Holiday Inn Santee by IHG stands out as an excellent family-friendly option in Santee, South Carolina, with an excellent traveler review rating of 8.2. This hotel offers spacious rooms that include cribs and connecting rooms, making it easy for families to stay close together while enjoying their own space. Find more child-friendly accommodations in Santee.
What are the top pet-friendly hotels in Santee?
Holiday Inn Santee by IHG is a fantastic option for pet-friendly travelers seeking a blend of comfort and convenience. This hotel welcomes small pets, ensuring that your furry friends can join in on the adventure. Guests appreciate the inviting indoor pool, great for a refreshing dip after a day of exploring, and the nearby golf course offers a delightful opportunity for those looking to tee off amidst beautiful scenery. See more pet-friendly hotels in Santee.
What are the best budget hotels in Santee?
For budget-conscious travelers seeking comfort and convenience in Santee, the Fairfield Inn & Suites by Marriott Santee stands out with an impressive guest review rating of 9.8. This hotel offers a delightful array of amenities, including complimentary breakfast options and free WiFi, ensuring a straightforward stay. Families will appreciate the outdoor pool, accessible fitness center, and the availability of cribs and highchairs, making it a welcoming environment for kids.

Another excellent choice is the Hampton Inn Santee-I-95, rated 9.6 by guests. This property also features an outdoor seasonal pool and offers free breakfast, creating the great start to a day of exploration. With spacious rooms equipped with cribs and rollaway beds, families can comfortably settle in without worry.

Couples looking for a cozy retreat may also enjoy the Best Western Plus Santee Inn, which, while slightly lower on the review scale at 8.8, boasts a charming atmosphere with an indoor hot tub and kitchen facilities for added convenience.

Each of these hotels provides a friendly and accommodating experience, allowing travelers to focus on their adventures while enjoying quality service without stretching their budget. View all budget hotels in Santee.
When is the best time to go to Santee?
The most popular time to visit Santee is April, when the weather is pleasantly warm, with temperatures typically ranging from the mid-70s to low 80s Fahrenheit. This delightful climate makes it superb for enjoying the area’s outdoor activities, such as hiking, golfing, or simply relaxing in one of the beautiful parks.

During the peak season from March to May, Santee attracts visitors who appreciate the vibrant atmosphere and opportunities for adventure. This is an ideal time to explore the stunning landscapes and partake in local events. With the pleasant temperatures, you can comfortably enjoy activities like picnicking at Santee Lakes or taking scenic walks along the trails.

For travelers who enjoy a bit of tranquility and still want to experience the charm of Santee, November presents a wonderful alternative. While it’s considered a low season, the weather remains mild, allowing for enjoyable outdoor activities without the crowds. This time of year is superb for connecting with nature, as the fall colors create a picturesque backdrop for your explorations.
Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel’s cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our “Fully refundable property” filter during your search to find the right Santee hotel for you.
How can I save on a Santee hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible Santee hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It’s free to join, and you’ll unlock our lowest Member Prices as soon as you’re signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Santee hotel?
Prices for hotels in Santee often vary, but you can find a great deal from $61 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by “Price: low to high” for the cheapest rate.